NutrEval® Plasma

A Comprehensive Test for Identifying Nutritional Deficiencies

Featuring Plasma Amino Acid Analysis

Proceed to Clinical Overview

Why Use the NutrEval Plasma Profile?

NutrEval Plasma® test is an advanced nutritional analysis designed to reveal nutritional imbalances or inadequacies. NutrEval Plasma evaluates the functional need for antioxidants, B-vitamins, minerals, essential fatty acids, amino acids, digestive support, and other select nutrients.

This nutritional analysis offers insight into nutrient status and allows clinicians to provide targeted treatment for the particular needs of each patient, often augmenting and speeding recovery of complex chronic conditions. Select genomic biomarkers may be added to the profile for enhanced personalization of therapies.

Introducing NutrEval® with Genomics

The Nutritional Test You Rely On Just Got Better!

We are excited to announce that we will now be offering select genomics testing (SNPs) on our most complete nutritional profiles: NutrEval Plasma amino acids and NutrEval Plasma amino acids.

Assessment of these select genomic markers in conjunction with the NutrEval supports broadened clinical insight and enhanced personalization of therapeutics in an array of patient conditions such as depression, anxiety, cardiovascular disease, cardiometabolic syndrome, inflammatory conditions, and chronic pain syndromes.

NutrEval kit requisitions will now include the option for ordering one or more of the following SNPs:

NutrEval with Genomics
  • MTHFR
  • COMT
  • TNF-α
  • APOE

Effective for Patients Experiencing:

NutrEval Plasma testing is effective for patient concerns such as:

  • Mood disorder
    • Depression
    • Anxiety
  • Fatigue
  • Digestive Complaints
  • Chronic Pain/Inflammatory Conditions
    • Musculoskeletal
    • Migraine
  • Cardiovascular Risk
  • Weight Issues/Dietary Guidance
  • General Health and Sports Fitness Optimization

About the NutrEval Plasma Profile

NutrEval Plasma is a nutritional analysis that allows assessment of nutritional inadequacies or imbalances that may be playing a causative role in complex chronic conditions.

The NutrEval Plasma report provides for easy interpretation and enhanced clinical utility and includes a Suggested Supplement Schedule that offers personalized recommendations based on test results. The report also includes an Interpretation-At-A-Glance page which depicts facts on nutrient function, causes and complications of their deficiencies, and dietary sources.

The complete NutrEval Plasma offers:

  • Metabolic Analysis (urine organic acids)
  • Plasma Amino Acid Analysis (essential and non-essential amino acids, plus intermediary metabolites)
  • Essential and Metabolic Fatty Acids (red blood cell essential and non-essential fatty acids, including Omega-3 and Omega-6 fatty acids)
  • Oxidative Stress Analysis (blood and urine biomarkers indicative of oxidative stress)
  • Elemental Markers (both nutrient and toxic elements)
  • Available SNPs – MTHFR, COMT, TNF-α, and APOE

A fasting plasma amino acid highlights the dynamic balance of the amino acid pool, independent of recent dietary intake. Plasma amino acid analysis is favored when the primary clinical consideration are conditions in which the supply of essential amino acid precursors is critical, such as in mood and neurobehavioral disorders. NutrEval with a urine amino acid analysis is also available: NutrEval FMV Amino Acids.

Clinical Overview

What is the NutrEval Plasma® Nutritional Analysis?

NutrEval is Genova's most comprehensive nutritional evaluation and is designed to assist with management of symptoms related to nutritional and digestive insufficiencies. This profile assesses numerous metabolic pathways and synthesizes this complex biochemistry into actionable treatment options. Critical nutrients that are functionally assessed on Genova’s nutritional profiles include:

  • Antioxidants
  • B Vitamins
  • Minerals
  • Essential Fatty Acids
  • Digestive Support

The personalized supplement recommendations, adjusted for the age and sex of the patient, guide therapeutic protocols in identifying clinical imbalances that may inhibit optimal health.

Studies suggest that even a balanced diet may not provide all essential nutrients. NutrEval supports assessment of a patient's nutritional needs by identifying nutritional deficiencies that may be associated with complex chronic conditions.

The Complete NutrEval Plasma Offers:

  • Metabolic Analysis Markers (urine organic acids)
    • Malabsorption and Dysbiosis Markers
      • Malabsorption Markers
      • Bacterial Dysbiosis Markers
      • Yeast/Fungal Dysbiosis Markers
    • Cellular Energy & Mitochondrial Metabolites
      • Carbohydrate Metabolism
      • Energy Metabolism
      • Fatty Acid Metabolism
    • Neurotransmitter Metabolites
    • Vitamin Markers
    • Toxin & Detoxification Markers
    • Tyrosine Metabolism

  • Plasma Amino Acid Analysis
    • Nutritionally Essential Amino Acids
    • Nonessential Protein Amino Acids
    • Intermediary Metabolites
    • Dietary Peptide Related Markers

  • Essential and Metabolic Fatty Acids
    • Omega 3 Fatty Acids
    • Omega 6 Fatty Acids
    • Omega 9 Fatty Acids
    • Saturated Fatty Acids
    • Monounsaturated Fats
      • Omega 7 Fats
      • Trans Fat
    • Delta-6 Desaturase Activity
    • Cardiovascular Risk – featuring key ratios: Omega 6/Omega 3, AA/EPA, and the Omega 3 Index

  • Oxidative Stress Markers
    • Glutathione (whole blood)
    • Lipid Peroxides (urine)
    • 8-OHdG (urine)
    • Coenzyme Q10 (plasma)

  • Elemental Markers
    • Nutrient Elements
      • Copper
      • Magnesium
      • Manganese
      • Potassium
      • Selenium
      • Zinc
    • Toxic Elements
      • Lead
      • Mercury
      • Antimony
      • Arsenic
      • Cadmium
      • Tin

The unique features of the NutrEval Plasma report provide for easy interpretation and enhanced clinical utility:

  • Colorimetric reporting signals key areas of concern
  • Synthesized results and actionable areas of high need for supplementation:
    • Results Overview Cover Page – provides the busy clinician with an immediate sense of patient areas requiring focus
    • Suggested Supplement Schedule – provides personalized recommendations for antioxidants, B-vitamins, minerals, essential fatty acids, digestive support, and amino acids
    • Interpretation At-A-Glance – provides patients with valuable information about the function of individual nutrients, causes and complications of their deficiencies, and their dietary sources

When Should a NutrEval Profile Be Considered?

Research suggests that nutritional shortfalls or imbalances may be at the root of many chronic conditions. The NutrEval can help identify specific, personalized recommendations for even the most difficult-to-treat patient cases.

Effective for Patient Concerns Such As:

  • Mood Disorders
    • Depression
    • Anxiety

  • Fatigue
  • Digestive Complaints
  • Chronic Pain/Inflammatory Conditions
    • Musculoskeletal
    • Migraine

  • Cardiovascular Risk
  • Weight Issues/Dietary Guidance
  • General Health and Sports Fitness Optimization

The NutrEval nutritional analysis is designed to assist in the management of nutritional imbalances or insufficiencies. It is ideal for establishing a baseline assessment ahead of clinical intervention with nutraceuticals as well as subsequent monitoring if needed.

What Advantage Does the Profile Offer Compared to Other Diagnostics?

Although practices are changing, the traditional medical model does not currently place emphasis on biochemical individuality. The conventional clinical approach to nutrition-related symptoms does not routinely include utilization of comprehensive nutritional testing. When testing is performed, select vitamins are assessed to determine if the level is sufficient to meet nutrient requirements based on healthy individuals. However, a comprehensive nutritional analysis – such as NutrEval Plasma – provides several advantages for patients with nutrient-related symptoms.

  • Identification of imbalances that may precede abnormal findings on standard laboratory panels
  • Comprehensive nutritional assessment indicating the functional need for specific nutrients, diet modification, antioxidant protection, detoxification and other therapies
  • Personalized nutrient recommendations based on biochemical individuality

What Can Clinicians and Patients Expect from NutrEval Testing?

Imbalanced or insufficient nutrients affect a wide range of body functions, producing symptoms that negatively affect the quality of life and, with some chronic diseases, may be considered a root cause. A structured comprehensive nutritional analysis – such as the NutrEval Plasma profile – to evaluate underlying imbalances provides clinical utility by supporting insight into development of personalized treatments. Identification and targeted treatment of underlying imbalance with customized nutrient recommendations can enhance other treatments and increase the patients’ overall health and ability to combat chronic illness.

NutrEval Plasma is Part of an Innovative Line of Nutritional Assessments:


Analyte List
1-Methylhistidine
2-Hydroxyphenylacetic Acid
3-Hydroxyproprionic Acid
3-Methyl-4-OH-phenylglycol
3-Methylhistidine
4-Hydroxyphenylpyruvic Acid
5-OH-Indoleacetic Acid
Adipic Acid
Alanine
Alpha-amino-N-butyric acid
Alpha-aminoadipic acid
Ammonia
Antimony
Arabinose
Arachidic
Arachidonic
Arginine
Arsenic
Asparagine
Aspartic acid
Behenic
Benzoic
Benzoic/Hippuric Acids Ratio
Beta-alanine
Beta-aminoisobutyric acid
Cadmium
Cis-Aconitic Acid
Citramalic Acid
Citric Acid
Citrulline
Copper
Creatinine
Cyst(e)ine
Cystathionine
Dihomo-gamma-linolenic
Dihydroxyphenylpropionic Acid
Docosahexaenoic
Docosapentaenoic
Docosatetraenoic
Eicosadienoic
Eicosapentaenoic
Elaidic
Ethanolamine
Formiminoglutamic Acid (FIGlu)
Gamma-Linolenic
Gamma-aminobutyric acid
Glucose
Glutamic acid
Glutamine
Glutaric Acid
Glutathione
Glycine
Gondoic
Hippuric
Histidine
Homogentisic Acid
Homovanillic Acid
Indoleacetic Acid
Isocitric Acid
Isoleucine
Kynurenic Acid
Lactic Acid
Lead
Leucine
Lignoceric
Linoleic
Lipid Peroxides
Lysine
Magnesium
Malic Acid
Manganese
Margaric
Mercury
Methionine
Methylmalonic Acid
Nervonic
Oleic
Ornithine
Orotic Acid
Palmitic
Palmitoleic
Pentadecanoic
Phenylacetic Acid
Phenylalanine
Phosphoethanolamine
Phosphoserine
Potassium
Proline
Pyroglutamic Acid
Pyruvic Acid
Sarcosine
Selenium
Serine
Stearic
Suberic Acid
Succinic Acid
Taurine
Threonine
Tin
Tricosanoic
Tryptophan
Tyrosine
Urea
Vaccenic
Valine
Vanilmandelic Acid
Zinc
a-Keto-b-Methylvaleric Acid
a-Ketoadipic Acid
a-Ketoglutaric Acid
a-Ketoisocaproic Acid
a-Ketoisovaleric Acid
alpha-Linolenic
b-OH-Butyric Acid
b-OH-b-Methylglutaric Acid
CPT Codes  
1-Methylhistidine 82139
2-Hydroxyphenylacetic Acid 83921
3-Hydroxyproprionic Acid 83921
4-Hydroxyphenylpyruvic Acid 83921
5-OH-Indoleacetic Acid 83497
Adipic Acid 83921
Antimony 83015
Arachidic 82542
Behenic 82726
Cadmium 82300
Citric Acid 82507
Copper 82525
Creatinine 82570
Docosatetraenoic 82726
Glutaric Acid 83921
Glutathione 82978
Homogentisic Acid 83921
Homovanillic Acid 83150
Isocitric Acid 83921
Lactic Acid 83605
Lead 83655
Lignoceric 82726
Lipid Peroxides 84311
Magnesium 83735
Malic Acid 83921
Manganese 83785
Methylmalonic Acid 83921
Nervonic 82786
Orotic Acid 83921
Potassium 84132
Pyruvic Acid 84210
Suberic Acid 83921
Succinic Acid 83921
Tricosanoic 82726
Vanilmandelic Acid 84585
Zinc 84630
a-Keto-b-Methylvaleric Acid 83921
a-Ketoadipic Acid 83921
a-Ketoglutaric Acid 83921
a-Ketoisocaproic Acid 83921
a-Ketoisovaleric Acid 83921
b-OH-Butyric Acid 83921
b-OH-b-Methylglutaric Acid 83921
Specimen Requirements
1 yellow-top tube - plasma Amino Acids (frozen); 1 amber tube - plasma (frozen); 1 blue-top Na-Heparin tube - Packed RBCs (refrigerated); 1 red-top neutral tube - serum (frozen); 1 EDTA tube 9mL - whole blood (refrigerated); 1 EDTA tube 4mL - whole blood (refrigerated); 1 blue-top amber tube - FMV urine (frozen); 1 green-top tube - FMV urine (frozen)