Metabolic Analysis Profile (Organic Acids)

The Metabolic Analysis Profile is a nutritional test that assesses urine metabolites in order to evaluate four critical areas of metabolism: gastrointestinal function, cellular and mitochondrial energy production, neurotransmitter processing, and amino acid/organic acid balance as influenced by vitamin/mineral cofactors. Results can be used to address chronic systemic complaints ranging from chronic fatigue and mood disorders to headache, muscular/joint pain, and digestive problems.

The Metabolic Analysis Profile is a nutritional test using an urinary assessment of 46 key organic acids grouped according to their primary roles in the following four central areas of metabolism.
Gastrointestinal Function — This profile measures eight markers that can reveal malabsorption and dysbiosis. These imbalances can be addressed to improve gut health and to help prevent or alleviate: chronic digestive problems, common causes of nutritional deficiency, yeast overgrowth, cognitive impairment, gastrointestinal distress, and degenerative conditions.

Energy Production —This profile assesses metabolites that serve as important intermediates in the citric acid (Krebs) cycle. This cycle supplies the body with its primary energy needs, converting 90% of food energy into cellular energy. This subpanel also includes:

  • Carbohydrate metabolites that can signal impaired glucose metabolism
  • Markers that help evaluate the breakdown of fats and production of cholesterol
  • A marker measuring the production of coenzyme Q10

Imbalances of cellular energy metabolites are linked with chronic fatigue, accelerated cell breakdown, and unhealthy aging.

Neurotransmitter Metabolites - A special grouping of neurotransmitter metabolites serve as important diagnostic indicators of abnormal metabolism that can underline many key aspects of neuropsychiatric function. These markers are urinary metabolites of powerful neurotranmitters that act on the central nervous system, including: Epinephrine, Dopamine, and Serotonin. These substances can profoundly influence patterns of stress response, emotional well-being, cognition, and sleep.

Assessment of Nutrient Sufficiency — This nutritional test provides a functional assessment of nutrient sufficiency and usage that covers a broad range of vitamins, coenzymes, elements, enzyme activators, and other nutrients.  An analysis of amino acid metabolites which require vitamin and mineral cofactors for their metabolism can hint at deficiencies of: vitamins B6, B12 and C, magnesium, copper, iron, and various amino acids.

The reference ranges for this test apply to children (2 — 12 years) and adults.

Test Type: Urine Test

Analyte List
2-Hydroxyphenylacetic Acid
3-Hydroxyproprionic Acid
3-Methyl-4-OH-phenylglycol
4-Hydroxyphenylpyruvic Acid
5-OH-Indoleacetic Acid
Adipic Acid
Arabinose
Benzoic
Benzoic/Hippuric Acids Ratio
Cis-Aconitic Acid
Citramalic Acid
Citric Acid
Creatinine
Dihydroxyphenylpropionic Acid
Formiminoglutamic Acid (FIGlu)
Fumaric Acid
Glutaric Acid
Hippuric
Homogentisic Acid
Homovanillic Acid
Indoleacetic Acid
Isocitric Acid
Kynurenic Acid
Lactic Acid
Malic Acid
Methylmalonic Acid
Orotic Acid
Phenylacetic Acid
Pyroglutamic Acid
Pyruvic Acid
Suberic Acid
Succinic Acid
Tartaric Acid
Vanilmandelic Acid
a-Keto-b-Methylvaleric Acid
a-Ketoadipic Acid
a-Ketoglutaric Acid
a-Ketoisocaproic Acid
a-Ketoisovaleric Acid
b-OH-Butyric Acid
b-OH-b-Methylglutaric Acid
CPT Codes  
2-Hydroxyphenylacetic Acid 83921
3-Hydroxyproprionic Acid 83921
4-Hydroxyphenylpyruvic Acid 83921
5-OH-Indoleacetic Acid 83497
Adipic Acid 83921
Citric Acid 82507
Creatinine 82570
Glutaric Acid 83921
Homogentisic Acid 83921
Homovanillic Acid 83150
Isocitric Acid 83921
Lactic Acid 83605
Malic Acid 83921
Methylmalonic Acid 83921
Orotic Acid 83921
Pyruvic Acid 84210
Suberic Acid 83921
Succinic Acid 83921
Vanilmandelic Acid 84585
a-Keto-b-Methylvaleric Acid 83921
a-Ketoadipic Acid 83921
a-Ketoglutaric Acid 83921
a-Ketoisocaproic Acid 83921
a-Ketoisovaleric Acid 83921
b-OH-Butyric Acid 83921
b-OH-b-Methylglutaric Acid 83921
Specimen Requirements
First morning urine collection; one tube of 10ml - needs to be full (samples frozen)